In the present investigation, an attempt has been made to test the hepatoprotective efficacy of the herbal plant, Trianthema decandra on carbon tetrachloride induced toxic hepatitis. The carbon tetrachloride induced rats showed higher level of total protein (TP), total cholesterol (TC), triglycerides (TG), Alkalin Phosphotase (ALP), Aspertatetransaminase (AST), Alananitransaminase (ALT) and bilirubin in serum. The leaf extract of T. decandra was treated with hepatitis rats showed remarkable reduction in the activity of TP, TC, TG, ALP, AST, ALT and bilirubin when compared to the normal rats. This research is suggests that the crude extract of T. decandra could be control the carbon tetrachloride induce hepatitis.