In the present investigation, in vivo antihyperglycemic activity of bark extracts of Ficus amplissima Smith. have been reported. Treatment of diabetic rats with bark extracts caused significant reduction in fasting blood glucose level in a dose dependent manner and after 14th days of treatment with extracts the body weight was significantly increased compared to the initial day. The result of present investigation reveals that the bark of the F. amplissima plant has potential biological activity, therefore suggested for further studies for purification and isolation of active phytoconstituents.