Aldose reductase is the key regulatory enzyme of the aldose reductase (AR)/polyol pathway which plays a major role in the development of diabetic retinopathy. Present study was an attempt to analyze the binding and interaction patterns of AR against 15 chosen active components of the herbal formulation Triphala in order to find a potent inhibitor of the enzyme. Molecular docking experiments were carried out using PatchDock online server. The protein ligand complexes thus obtained were analyzed on PyMol viewer. Phytochemicals such as ellagic acid, sennoside, ellagitannin, chebulinic acid, vitamin C and casuarinin showed significant interactions with AR. Of these ellagitannin was identified as a potent inhibitor of AR showing 18 hydrogen bond interactions.Therefore, this potential flavonoid could be used to prevent diabetic retinopathy and used as a potential therapeutic approach to diabetic retinopathy targeting AR.