Many different plants have been used in traditional medicine to regulate fertility or to treat infertility. In Urmia ethnobotany, different medicinal plants are also used to treat various diseases, so the aim of the present study was to identify and report the medicinal plants which are effective in treatment of reproductive system disorders in Urmia. Semi-structured interviews and questionnaires were carried out between 2013 June and 2014 February in Urmia. The results of this study indicated that a total of twenty seven native medicinal plants have been used in the treatment of dysmenorrhea, uterine and vaginitis infections, impotency, prostate and etc. Most of the drug information of the present study is new, and awareness of these applications can be helpful in discovery of new applications for industrial pharmacology.