Diabetes mellitus is a chronic health condition in which the body either fails to produce sufficient amount of insulin or it responds abnormally to insulin. Current treatments, besides proper diet and exercise, include sulfonylureas, meglitinide, biguanide, thiazolidinedione, and alpha-glucosidase inhibitors; however, these are costly and not without side effects. The present study explores the hypoglycemic properties of Antides mabunius fruit ethanolic and aqueous extracts on alloxan-induced hyperglycemic ICR mice. For this study, diabetic mice were treated with 100 mg/kg, 300 mg/kg or 500 mg/kg aqueous fruit extract or ethanolic fruit extract via oral gavage and observed for 14 days. Measurement of their Fasting Blood Glucose levels (FBG) on the 3rd, 7th, 10th and 14th days show that all treatments were able to lower FBG levels, with 500 mg/kg ethanolic fruit extract being the most effective. Preliminary phytochemical screening shows positive results for phenols, indoles, steroids and flavonoids. The study shows that of A. bunius ethanolic fruit extract as a potential herbal drug candidate for the treatment of diabetes.