The purpose of this study is to investigation the process of alteration main elements along with fluoride in the region's water, their relation with each other and also with geology and human made activities of this basin. In order to gain this purpose, 25 samples of groundwater were studied on December, 2013. Moreover, statistics methods such as correlation matrix, the main component analysis, and cluster analysis with the SPSS softer were used to evaluation of the relations between water resources and the elements dissolved in water. Result showed that fluoride concentration increase, from upstream to downstream (from 1 to 4 mg/L). Also result of the primary test showed that some of the main elements and physicochemical parameters such as sodium, sulphate, chlorine, electric conductive, and some of the soluble electrolyte increase, from upstream to downstream while bicarbonate decreases. The result taken from the main component analysis represents the presence of different elements in different groups. Furthermore, the cluster analysis categorizes the water resources into 3 classes and it represented that water resources in downstream are completely different from the other resources in their constructive elements. The correlation coefficient of ions showed that correlation of Fluorine with calcium sodium and sulphate was positive and with bicarbonate a pH was negative. Piper's diagram also showed that faces and types of upstream samples are Bicarbonate Magnesia - calcic and sodic and downstream samples are sulphate sodic. Result showed that fluoride concentration in the region's water (2 to 8-fold) more than normal range in in the region's water the level found in the water with fluoride concentration normal range (0.5 mg /L). These findings provide a basis for further studies on evaluation of serum and urine fluoride concentration of animals and humans that use in the region's water.