Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2015 Vol: 7 Issue: 5

Host-guest complexes of baicalein and silybin with C-hexylpyrogallol[4]arene: Determination of the stoichiometry and the mode of binding

Abstract

Apart from the trapping of metal ions by the various calixarenes, C-Hexylpyrogallol[4]arenes are studied for their host–guest interactions with the organic guest molecules. In this article, we report the host–guest association of a flavone, baicalein and a chromanone, silybin with C-Hexylpyrogallol[4]arene. The stoichiometry for the inclusion of these guest molecules with C-Hexylpyrogallol[4]arene is determined as 1:1 ratio by Benesi–Hildebrand equation. The strength and mode of binding of baicalein and silybin with is supported by time-resolved fluorescence, nuclear magnetic resonance correlation spectroscopic techniques and molecular docking studies. The structure of the inclusion complex is proposed.

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