The parasitic infection becomes more common nowadays, mortality due to coccidiosis in poultry birds are increasing day by day. This kind of infection will affect the production and economy of poultry farms, mostly this infection are caused by parasites of Genus Eimeria affects birds such as poultry and mammals such as cattle and rabbits. Hence, it is necessary to control the death of the birds through a novel approach. This study is mainly investigated on the targeting the crucial enzyme S-Adenosylmethionine synthase present in E.maximum. The 3D structure of the S-Adenosylmethionine synthase is modeled using homology modeling techniques and docking with 1-monocaproin, found the binding energy as -2.85kcal/mol. The interaction is observed in Gly and Phe amino acid present in the S-Adenosylmethionine synthase. Hence in future, passing out the trails it can be used as one drug candidate for treating this poultry disease caused by E.maximum.