A simple, accurate High Performance Thin Layer Chromatographic (HPTLC) method for determination of Dexketoprofen and Thiocolchicoside in combined tablet dosage form has been developed and validated. The mobile phase selected was Toluene: Methanol: Ethyl Acetate (6: 2.5: 0.5, v/v/v) with UV detection at 280 nm. The retention factor for Thiocolchicoside and Dexketoprofen were found to be 0.33 ± 0.011 and 0.61 ± 0.007, respecti vely. The method was validated with respect to linearity, accuracy, precision and robustness as per the International Conference on Harmonisation (ICH) guidelines. Results found to be linear in the concentration range of 100-800 ng/band for Thiocolchicoside and 600-4800 ng/band for Dexketoprofen. The method has been successfully applied for the analysis of drugs in pharmaceutical formulation. The % assay (Mean ± S.D.) was found to be 100 .07 ± 0.872 for Thiocolchicoside and 99.97 ± 0.731 for Dexketop rofen. The method can be used for routine analysis of these drugs in combined tablet dosage forms in quality-control laboratories