The Neem tree ( Azadirachta indica ) has been known as the wonder tree for centuries i n the Indian subcontinent. It has become important in the global context today because it offers answers to the major concerns facing mankind.Neem (Azadirachta indica) is considered harmless to humans, animals, birds, beneficial inse cts and earthworms, and has been approved by the US Environmental Protection Agency for use o n food crops. Azadirachtin and other active ingredients in the neem seed have insecticidal prop erties that are effective against a broad spectrum of insects, many mites and nematodes, and even snails and fungi, and do not seem to generate resistance in the pests they affect. Nowad ays, neem and its extracts are used in numerous herbal and allopathic medicines. What's mo re, even neem contraceptives are available in the market these days.Neem extract which have Ni mbinin, nimbandiol as active constituents, alcoholic extract of the leaves was found to posses s a significant blood sugar lowering effect, which are very useful against diabetes. Neem is use d in Dermatitis Eczema, Acne, Bacterial, Fungal infections and other skin disorders. It has demonstrated its effectiveness as a powerful antibiotic. Neem also has shown antiviral, anti-fun gal and anti-bacterial properties. It helps support a strong immune system and is used in cases of inflammatory skin conditions. Traditionally Neem has been used for skin and blood purifying conditions. Neem not only helps in curing diseases, but it also provides us with th e strength of fighting diseases by enhancing our immunity.