The ethanolic extract of the whole plant of Anisochilus carnosus (Lamiaceae) was evaluated for hepatoprotective activity in wistar rats with liver damage induced by paracetamol. The extract of an oral dose of (200 mg/kg, bw and 400 mg/kg, bw p.o.) exhibited a significant protective effect against paracetamol induced hepatotoxicity by lowering the serum levels of aspartate aminotransferase (SGOT), alanine aminotransferase (SGPT), total serum bilirubin, and malondialdehyde equivalent, an index of lipid peroxidation of the liver. The activity of the ethanolic extract of Anisochilus carnosus whole plant was comparable to the standard drug, silymarin (100 mg/kg, p.o.), and the histopathological studies supports the above finding. Results indicate that Anisochilus carnosus possesses significant hepatoprotective effect on paracetmol -induced hepatotoxicity in mice.