The liver, through its multiple functions, is actively involved in the metabolic homeostasis of the body. However, it is not spared from various aggressions like other organs, which can lead to significant damage. Carbon tetrachloride is known in experimental models to be hepatotoxic, causing fibrosis, cirrhosis, and hepatocarcinoma. The aim of this study is to induce hepatotoxicity in Wistar rats and then treat them with both aqueous and ethanolic extracts of Lophira lanceolata leaves at different doses of 500 and 1000 mg/kg of body weight. Following the obtained results, the values of liver biochemical parameters indicating hepatic damage (AST, ALT, TB, CB, GGT, ALP) were significantly elevated 48 hours after the induction of hepatotoxicity but decreased significantly one week later compared to control rats. These biochemical results were confirmed by histological sections of the livers of intoxicated and treated rats. Phytochemical screening of the extracts revealed alkaloids, flavonoids, tannins, polyphenols, saponins, anthocyanins, quinonic derivatives, reducing compounds, and leuco-anthocyanins, and HPLC revealed many chemical compounds, especially flavonoids such as rhamnetin, flavone, rutin, quercetin, luteolin, flavone, which are believed to possess hepatoprotective properties.