One-pot, three-component condensation reaction between (phenylsulfonyl) acetonitrile, aromatic aldehydes, and 4-hydroxy carbazole for preparation of 4,10-dihydro-4-Aryl-3-(phenylsulfonyl) pyrano[2,3-b]carbazol-2-amine derivatives has been reported. The method involves domino Knoevenagel condensation/Michael addition, and cyclization cascade. The reaction was performed in glycerol, which is a commercially available, inexpensive and non-toxic compound. High purity of the products, very high yields and wide scope of substrates are advantages of this protocol.