Nimbapatradi Choornam is a known Ayurvedic medicine for Leprosy, eczema, gout, leukoderma, skin eruptions and psoriasis. The ingradiaents of Nimbapatradi choornam are neem leaves, sulphur and turmeric, which are known for their antiseptic properties. The present study is to understand the medicinal efficacy of Nimbadipatra choornam undertakig phytochemical analysis, antimicrobial activity effect, antioxidant effect and GC MS analysis. The phytochemicals present were saponins, tannins, triterpenoids, cardiac glycosides, phytosterol, coumarin and phenolic compounds. Strong antimicrobial activity of this medicine was onbserved against the microorganisms such as, Klebsiella pneumoniae, Staphylococcus aureus, E coli and Candida albicans. The antioxidant activity of Nimbapatradi also was found in three types of asays namely, reducing power assay, peroxidase assay and catalase assay. The GC MS patterns have shown important peaks which represented Cyclic octatomic sulfur S8, Phenol, 2,4- bis(1,1-dimethylethyl)-derivative, Ar-tumerone, Isopropyl myristate, Eicosane, 2-methyl-derivative, Cyclopropaneoctanoic acid, 2-[(2-pentylcyclopropyl)methyl]-, Octadecanoic acid, 2-hydroxy-1-(hydroxymethyl) ethyl ester, Hexadecanoic acid, ethyl ester, 7,9-Di-tert-butyl-1-oxaspiro(4,5)deca-6,9-diene-2,8-dione, 3- Hexadecanol, Ergosterol etc. The presence of these biocactive compounds correspond well with the activity of Nimbadipatra choornam as a stong medicine for skin related diseases.