This study subjected the flavonoids, alkaloids, saponins and tannins isolated from Combretum dolichopentalum to Gas Chromatographic-Flame Ionization Detector (GC-FID) analyses. Keampferol (295915±18219.31 x10-4 mg/100g), akuamidine (41.452±1.339 x10-3 mg/100g) and sapogenin (6153.76±602.44 x10-2 mg/100g) showed the highest concentration of flavonoid, alkaloid and saponin respectively. The phytochemicals identified and quantified in C. dolichopentalum indicate bioactive compounds with pharmacological potentials. The plant constituents could act as antioxidants and used as anti-inflammatory, hypotensive, anticholesterolemic, antiarrythmic agent in the treatment and/or management of diseases and disease conditions.