The protein levels in serum, liver and brain digests in aluminum intoxicated male wistar rats were investigated. Twenty-four male wistar rats weighing between 150- 205g were used. The rats were divided into four separate groups and were treated as follows: while group A received 0.2 ml normal saline groups B-D received 0.38 mg/kg, 3.8 mg/kg and 38 mg/kg body weight aluminum as aluminum chloride (AlCl3) respectively. Normal saline served as vehicle for the administration of the toxicant. The results of this study show that the aluminum-treated groups had significant reduction (p<0.05) in protein levels as compared to the control. The reduction in serum, liver and brain protein levels observed were dose and duration dependent suggesting that aluminum administration to rats probably interfered with protein synthesis.