The problem of variable oral bioavailability of Glibenclamide (GB) a poorly water-soluble oral hypoglycemic agent has been examined and out the different techniques available like micronization, co-solvent, change in dielectric constant, chemical modification of drug and complexation methods, this work investigated the possibility of developing solid dispersions of glibenclamide with different hydrophilic carriers, such as PEG 6000, PVP K30, sorbitol, mannitol, mannitol, citric acid and urea in different concentrations (1:2.5, 1:5, 1:7.5, 1:10, 1:12.5 and 1:15) by solvent evaporation method. Solid dispersions obtained from PEG6000 (1:5) gave the best dissolution profile, showing double quantity of drug dissolved in 15 min as compared to pure glibenclamide (control).The FTIR spectra depicted possible interaction of drug and carrier while DSC and X-ray diffraction pattern indicated that the dispersion had an amorphous nature. The product was found to be stable and no significant alteration in the dissolution efficiency was observed after storage for 90 days at 45 ± 2°C.