The purpose of the present investigation was the formulation and characterization of mucoadhesive sustained release microsphere of antihyperlipidemic drug simvastatin that would adhere in mucosa and release continuously to provide long term effect. There was various formulations of simvastatin were prepared by solvent evaporation technique using hydroxypropyl methylcellulose (HPMC), Carbopol, Xanthan gum, Guar gum as a polymer. The prepared mucoadhesive microspheres were evaluated for particle size, surface morphology, drug entrapment efficiency, Drug content, buoyancy percentage and In-vitro drug release, In-vitro adhesion test and stability studies. The particle was found to be discrete and spherical with the average particle size in the range of 105.54-396.6μm. As the concentration of polymers increases it affects the various evaluation parameters like particle size, in-vitro drug release and In-vitro adhesion. The Mucoadhesive microspheres of optimized formulation exhibited the prolonged release of 88.28% in continuous manner up to 8 hrs. It is concluded that the optimized formulation of simvastatin mucoadhesive microspheres can be selected for sustained drug delivery system for improved bioavailability.