Orodispersible tablets, also called as mouth dissolving tablets, are the formulations which dissolve or disperse in the saliva and do not require water for administration, thus are good alternative for travelers, bed ridden patients, dysphagic, geriatric and pediatric patients. The purpose of the present study was to formulate orodispersible tablets of levocetirizine dihydrochloride as it quickly disintegrate and disperse in the saliva. Superdisintegrants like Sodium starch glycolate (SSG), Crosscarmellose sodium (CCS) and Crosspovidone(CP) were used for the formulation. A total of twelve batches were formulated. The tablets were fabricated by direct compression method. All the formulations were subjected to in-vitro tests like wetting time, disintegration test and dissolution test. The effect of superdisintegrants on wetting time, disintegration time and dissolution profile was evaluated. The in-vitro study showed that increasing the concentration of superdisintegrants lowers the wetting time (WT) and disintegration time (DT) and enhances the drug release percentage of the formulations. The formulation with SSG 6% and CP 4.5% was the most effective formulation as it showed wetting time of 25 seconds, disintegration time of 30 seconds and cumulative % drug release of 68.12 and 104.20% at 1 and 10 minutes respectively. The study showed that the formulations containing SSG and CP as the superdisintegrants showed better drug release pattern than the formulations with other superdisintegrants. The study also showed that SSG as the superdisintegrant was more effective for the formulation of orodispersible tablets of levocetirizine dihydrochloride.