Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2010 Vol: 2 Issue: 5

Formulation and evaluation of Valsartan film coated tablets

Abstract

Valsartan used for the treatment of Hypertension, which is a specific angiotensin II receptor blocker (ARB) acting on the AT1 receptor subtype, The purpose of the present work is to formulate and evaluate of Valsartan film coated tablets. In order to obtain the best optimized product, eight different formulations were developed using diluents, binder, glidant, lubricant, and different concentrations of superdisintegrant. Tablets were formulated by direct compression, slugging and wet granulation techniques. Various pre-compressional parameters like bulk density, tapped density, compressibility index and Hausner’s ratio and post compressional parameters like weight variation, thickness, hardness, friability, disintegration time, and drug release were studied. Comparatively granulation techniques exhibited the good powder flow than direct compression technique. Based on this investigation results, the drug release from tablets increased with increasing concentration of superdisintegrant. The formulation F-7 was showed good drug release and selected as an optimized formulation and it was concluded that superdisintegrant concentration, granulation technique, binder, and lubricants plays a key role in the formulation development and optimizing the immediate release tablet of Valsartan formulation

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