A liposomal reservoir system bearing the anti-fungal, tolnaftate, was developed for better-permeable, controlled and localized delivery via topical route. Different charged liposomes were developed by dried thin film hydration technique and incorporated to carbopol gel. The developed gels were characterized for particle size, poly-dispersity index, drug content, spreadability, microbial assay and in vitro permeation. Antifungal efficacy of developed gels was assessed by the in vivo studies in albino wistar rats. The mean particle size of neutral, negative and positive liposomes was 119 nm, 143 nm and 284 nm respectively. Among the three different liposomes neutral charged has exhibited higher entrapment efficiency about 88.14%. The animals have shown complete sign of cure on the 13th day of the drug therapy. Small sized vesicle of developed liposomal gel formulation attributed higher permeation and faster cure rate than the available marketed formulation. So, this study ensures that liposomal carriers have a high potential in topical drug delivery and can overcome the permeability and efficacy problems.