Fenofibrate is a lipid lowering drug used in the treatment of hyperlipidemia, which is not soluble in water and lower absorption in gastric fluid. In order to improve the solubility and oral absorption of the drug in gastric fluid and to enhance its dissolution rate solid dispersions is designed and evaluated. Solid dispersions of Fenofibrate were prepared by using various ratio of different carrier like PEG-400,6000, MCC, pregelatinized starch, cremophor, etc., (formulations from F1 to F9 and one reproducibility batch F10 were formulated). Then prepared solid dispersions were evaluated for invitro dissolution, DSC, and also stability studies were conducted. Solid dispersion with PEG were formulated in different ratio. The differential scanning calorimetry demonstrated that enhanced dissolution of Fenofibrate from solid dispersion might be due to a decrease in the crystallinity of Fenofibrate in carrier in solid dispersion preparation. PEG, MCC, pregelatinized starch has increased the solubility and bioavailability of Fenofibrate significantly.