As reported in the literature, Ramipril has poor bioavailability, easily undergoes first pass metabolism. Hence an attempt was made to prepare mucoadhesive buccal films containing Ramipril as model drug. Various films were prepared by employing sodium alginate with different ratios. The prepared films were evaluate for their physical parameters like thickness and size, folding endurance, drug content, bioadhesive strength etc… The drug conten of all the formulations was found to be uniform. The ex-vivo diffusion studies were conducted with franz –diffusion cell. The results indicated that the film prepared with 650 and 325mg of sodium alginate showed sustained drug release. To these two formulations 30% of the plasticizer was added. Only F2 and F9 showed significant drug release. Films are having 50% of plasticizer and permeation enhancer shown fast drug release at the end of 7 and 10hrs. IR studies showed no interaction between drug and polymer. Dissolution studies were conducted for all the formulations only F3 formulation showed 90% of drug release in 7hrs.