The purpose of the present study was to formulate polyethylene oxide and polyvinyl alcohol nanoparticulate system of Rivastigmine for drug delivery to brain. Nanoparticles were prepared with poly ethylene oxide (PEO) by solvent displacement technique stabilized by polyvinyl alcohol (PVA). The Prepared nanoparticles were characterized for pH, particle size, surface morphology, entrapment efficiency,In vitro release, zeta potential. Compatibility studies indicated replication of spectral peaks in the study indicated drug and excipients were compatible with each other. The particle size was determined by Malvern zeta sizer. The average particle size was 100.7 nm with polydispersity index of 0.232.The zeta potential of the optimized formulation D1 was determined and found to be 34.8 mV. Surface properties of the nanoparticles were studied by Transmission electron microscopy (TEM) and nanoparticles found to have smooth surface. The Drug entrapment efficiency was found to be in between 67.5 to 86.53% indicated fairly good drug loading in the formulations indicated increased bioavailability of the drug. Percentage drug release data of optimized formulation D1 fitted in Higuchi’s plot indicating diffusion and erosion mechanism of drug release from the developed formulations.