Dispersible tablets of Norfloxacin were prepared using natural substances as disintegrant such as Ispaghula husk powder, Cassia tora powder, Cassia tora powder (defatted), and Cassia nodosa powder in different concentration by direct compression method. Formulations were evaluated for the standard of dispersible tablets and were compared with marketed products. It was observed that all the formulations were acceptable with reasonable limits of standard required for dispersible tablets. The study reveals that natural gums used as disintegrants were effective in low concentration