The present research aims to enhance the dissolution profile of Telmisartan through formulation of its fast disintegrating tablets using a super-disintegrant Ac-Di-Sol. The effect of super-disintegrant Ac-Di-Sol was studied mainly on disintegration time and in-vitro drug release. A 22 factorial design was employed in formulating the fast disintegrating tablets. The selected independent variables Ac-Di-Sol and microcrystalline cellulose showed significant effect on dependent variables i.e. disintegration time and percent drug dissolved. The disintegration time and percent drug dissolved decreased with increase in the concentration of Ac-Di-Sol and decrease in the concentration of microcrystalline cellulose in the tablet. The optimized formulation was compared with the conventional marketed formulation for the same dependent variables. It showed about 62% increase in dissolution rate. The study concluded that dissolution rate of Telmisartan could be enhanced using Ac-Di-Sol as a super-disintegrant.