The aim of the current investigation was to fabrica te domperidone floating matrix tablets by using var ious release retardants from natural and synthetic origin. Dompe ridone is a synthetic benzimidazole compound and we ak base in nature, acts as a dopamine D 2 receptor antagonist and used as pro-kinetic agent. Its short biological half-life (4- 7H), low bioavailability and rapid absorption chara cteristics in proximal part of GIT enable it as a s uitable candidate for floating matrix tablets. Floating mat rix tablets were prepared by direct compression met hod employing several hydrophilic swellable polymers li ke HPMC K100M, Carbopol-934P, Sodium alginate, Guar gum and Gellan gum in various combinations. NaHCO 3 and Citric acid were used as gas forming agents. P repared tablets were evaluated for parameters such as swell ing study, lag time, buoyancy time, in vitro dissol ution studies etc. A modified buoyancy lag time for tablets was d etermined in order to include the effect of bioadhe sion on initial buoyancy. Fourier transform-infrared spectroscopy, Differential scanning calorimetry and X-ray diffrac tion studies were also carried out for the optimized batch F7. F rom this investigation, it was observed that for op timized batch F7 the buoyancy time was achieved up to 12 H and th e amount of drug release was around 96.25% within 1 2H. After linearization of the results obtained in the dissolution test, the best fit with higher correlat ion coefficients (r 2 ) was shown in zero order for optimized batch F7 and the mechanism was found to be non-Fickian or anomal ous diffusion according to Korsemeyer’s-Peppas equation .