Floating matrix tablets of clarithromycin were developed to prolonged gastric residence time and thereby increase drug availability. The tablets were formulated by wet granulation technique, using polymers such as Guar Gum, HPMC-K15M and HPMC-K100M, and other standard excipient. Tablets were evaluated for physical characteristics viz, hardness, percentage friability, floating capacity, weight variation and content uniformity. Further, tablets were evaluated for in-vitro release characteristics for 12hr. Increasing the polymer ratio the FLT was increase but the drug release was decreased.