Natural products have been the source of most of the active ingredients of today’s medicines. Now a day this knowledge of ethnic use in medicines is being explored in much extent. At the end of 20th century, nearly half of the drugs approved are either were natural products or inspired by a natural compound. Despite these advantages, many large pharmaceutical companies have decreased the use of natural products in drug discovery screening due to the complexities present in natural compounds. Hence it becomes necessary to initially screen these natural compounds that exhibit multitargeted action. Therefore, biological activity has to be balanced with “drug-like” properties, and the closer we get to a candidate compound, the more important drug-likeness it becomes. So, PASS (Prediction of Activity Spectra for Substances) was employed as a feasible strategy so as to describe the biologically active properties of phytoconstituents. The present paper describes the application of online PASS for the evaluation of biological activity of main phytoconstituents in selected anti-inflammatory plants. Furthermore the unexplored but PASS predicted activities for particular phytoconstituents were described as hidden potential of these plants.