Oral route of drug administration is the most common and preferred route of administration. Oral dispersible tablets (ODT) are oral solid dosage forms that disintegrate in the oral cavity in easy swallow residue. Efavirenz which is an oral nucleoside reverse transcriptase inhibitor (NRTI) of human immunodeficiency virus. The project was aimed to enhance the solubility which intern improves the bioavailability. DESIGN EXPERT version 8.0.7.1 was selected for designing of the present project to make the project economical and statically significant. Superdisintegrates (croscarmellose sodium, sodium starch glycolate) used in different concentrations. Prepared tablets were evaluated for various in-vitro evaluation tests such as weight variation, thickness, wetting time, drug content, in-vitro disintegration time, in-vitro dissolution. The formulations are analyzed for considered response i.e. disintegration, dissolution with the help of DESIGN EXPERT software and the based on the considered responses an optimized formulation was developed. The optimized formulation developed showed the in-vitro drug release greater than 80% within 30min and 96.67± 1.18 within 60min.