+44 1625708989Original Articles: 2017 Vol: 9 Issue: 10
Expeditious Synthesis of 3-Aryl Benzothiophene A Raloxifene Intermediate
Abstract
A cyclodehydration of aryl thioacetyl compound with aluminum chloride to form 3-Aryl-6-methoxy thiofurans was an important step in the synthesis of raloxifene hydrochloride. Aryl thioacetyl compound was prepared in a single step from 3-methoxy benzenethiol and 4-methoxy phenacylbromide.