The measurements of density, viscosity and velocity have been determined by experimental procedures using specific gravity bottle, Ostwald’s viscometer and ultrasonic interferometer technique at frequency of 2 MHz and at constant temperatures of 303.15,308.15 and 313.15K respectively Ultrasonic velocities (u), densities (ρ) and viscosities (η) have been measured for the binary liquid systems (1M NaCl+1M Serine). Using experimental data, derived thermodynamic parameters such as adiabatic compressibility (βa), intermolecular free length (Lf), acoustic impedance (z), and relative association (RA) have been computed using standard formulae. The results have been interpreted on the basis of variations in thermodynamic parameters and excess parameters. The variations in ultrasonic velocity and adiabatic compressibility with concentrations in these liquid systems at frequency of 2 MHz and at all temperatures shows a similar trend of increasing ultrasonic velocity and decreasing in adiabatic compressibility of the constituent amino acids. Again, this is due to complex formation and coordinate covalent bonds formed between the molecules of the liquid mixtures. Excess thermodynamic parameters i.e. excess adiabatic compressibility (βa E), excess intermolecular free length (Lf E), excess acoustic impedance (zE), and excess relative association (RA E) have been calculated. The presence of ion – ion, solute – solvent (Amino acid, electrolyte and water) interactions is noticed in the mixed aqueous systems.