The study evaluated the analgesic effects of methanolic extract of Cissus aralioides leaves in rats. The analgesic effects of C. aralioides was evaluated using acetic acid induced writhing reflex and tail flick models in rats. The administration of the extract at the doses of 150, 300 and 600 mg/kg body weight to the rats resulted in a significant (P < 0.05) decrease in the number of writhing reflexes in rats in a dose dependent manner when compared to tween- 20 solution treated group (negative control). In the tail flick model, Pre-treatment of the rats with Aspirin (100 mg/kg), extract (300 and 600 mg/kg) produced 59.25%, 21.71% and 22.59% increase in pain reaction time (PRT) respectively, when compared to the negative control group. The result of the study suggests that Cissus aralioides possesses analgesic properties and provides the pharmacological basis for its use in ethnomedicine for this purpose.