Aim of the current study was to investigate the immunomodulatory potential of Grewia asiatica extract on cyclophosphamide induced myelosuppression, forced swimming test and carbon clearance test in Swiss albino mice. The assessment of immunomodulatory activity was studied by cyclophosphamide induced myelosuppression, forced swimming test and carbon clearance test. Cyclophosphamide (30 mg/kg, i.p.) was used to induced immunosuppression in mice, levamisole (50 mg/kg, p.o.) and ashwagandha (100 mg/kg, p.o.) used as standard immunostimulating agents. The ethanolic extract of Grewia asiatica (GAEE) fruits was administered orally at two dose levels of 200 and 400 mg/kg body weight in mice. Ethanolic extract of Grewia asiatica showed significant counteracting effect to cyclophosphamide-induced reduction in total WBC, % neutrophil and haemoglobin levels. Furthermore, after daily oral administration of Grewia asiatica, immobility time was decreased significantly in the Grewia asiatica administered group (200 and 400 mg/kg) on day 10. On the other hand, animals treated with GAEE, showed increase in the phagocytic index in carbon clearance assay. The present study clearly indicated immunostimulant property of GAEE and lends support for further development of new immunostimulant drug.