The plant of Oroxylum indicum is reported to possess anti-epileptic activity in ethnomedicine books. So, looking for dire need of a new, safe and economical anti-epileptic agent we focused to investigate anti-epileptic potential of Oroxylum indicum. Methanolic extract of Oroxylum indicum leaves was prepared & subjected for various animal models to evaluate anti-epileptic activity. Anti-epileptic activity was evaluated by PTZ and MES induced seizure model followed by CNS-depressants action by Actophotometer apparatus. Methanolic extract of Oroxylum indicum shown significant decrease in time of Myoclonic jerk and tonic flexation in PTZ model & decrease in time of tonic convulsion and clonic expansion in MES model. This study also shown that number of cut-off is also decrease in actophotometer. (Significance level P < 0.005 ≈ highly significant). Animal model show remarkable beneficial effect in PTZ induced seizure as well as MES induced seizure. Along with that study on Actophotometer revealed that MEOI can act as CNS-depressants. Considering all these findings, we can conclude that Methanolic extract of Oroxylum indicum leaves possess CNS-depressant activity which can be therapeutically useful in management of Epilepsy.