The main aim of the present investigation was to appreciate the diuretic and natridiureticactivities and the toxicity from Elaeis guineensis leaves aqueous extract (EGLAE). After orally administration of the aqueous extract at doses of 67.5 mg/kg, 135 mg/kg and 202.50 mg/kg (body weight) to Wistar rat, the volume of urine excreted and the quantity of ions (Na+, K+) are respectively determined in stepped up test-tube and by ionic spectrophotometrically measuring. The results show that the urine of Wistar rathas a pH between 6.1 and 8.6 with an average of 7.35 ± 1.25. Diuresis basic after six hours is 7.8 mL. A significant diuretic activities (157.16%, 169.25%) areobserved in Wistar rattreated respectively with 135 mg/kg of EGLAE and furosemide (as reference drug, 20 mg/kg) and a modest diuretic activity (146.32%) with a dose of 202.50 mg/kg of EGLAE. Itnatridiuretic activity was 2.34 at same dose of 135 mg/kg against 2.52 for furosemide (20 mg/kg) and 0.75 for distilled water. The dose of 135mg/kg is the best in terms of diuretic and natridiureticactivities.IC50 of larval toxicity of aqueous extract on Artemia salina has evaluated to be1.710 mg/mL.