The study was carried out to find out the antiulcer activity and thrombolytic activity of aqueous extract of Tiliacora acuminate. For this study albino Wistar rats(150-200g) were used .Four groups of rats were selected containing six animals in each group. The study was carried on different gastric ulcer models and ulcers were induced by pyloric ligation and aspirin. The animals were treated with Omeprazole 20mg/kg and AETA 200 and 400mg/kg. Ulcer index was calculated in both models. In pyloric ligation model, free acid, total acid, and total protein were also determined. Thrombolytic activity also determined. AETA produced significant reduction in ulcer index (0.72) when compared with control (4.5) in both ulcer models. In pylorus ligated model it showed significant reduction in volume of acid secretion and increased mucin and total protein content .It also produced significant increase in Free radical scavenging and lipid peroxidation content. AETA produces significant antiulcer activity which is comparable to standard drug Omeprazole. It also produces significant Thrombolytic which is comparable to standard streptokinase.