The present study was aimed to screen Ricinus communis (RC) leaves for anti-inflammatory potential using carrageenan-induced paw edema (Acute model) and cotton pellet induced granuloma models (Sub-chronic model) in Wistar rats. For this 80% methanolic extract (ME) at two dose levels of 250 and 500 mg/kg and total flavonoids fractions (FF) at three different doses 25, 50 and 100 mg/kg, were studied in acute model. The ME (500 mg/kg) and FF 50 mg/kg showed potent anti-inflammatory action in this model, Moreover FF (50 mg/kg) had shown almost same effect as shown by FF at the dose of 100 mg/kg. Hence, ME (500 mg/kg) and FF (50 mg/kg) have been selected for further evaluation in sub-chronic model. The results of ME (500 mg/kg) and FF (50 mg/kg) were at par with diclofenac sodium (20 mg/kg). The study shows the RC leaves have anti-inflammatory potentials and flavonoids are dominating this activity in the extract.