Many Ayurvedic antidiarrhoeal formulations contain Punica granatum L, (Puniacaceae) as one of the ingredient. Efficacy of Punica granatum L. in polyherbal antidiarrhoeal formulation was evaluated by comparing its antidiarrhoeal activity with Mebarid; an antidiarrhoeal Ayurvedic formulation. Antidiarrhoeal effect of an aqueous extract of rinds of fruits of Punica granatum (APG) and Mebarid was studied in castor oil induced diarrhoea, intestinal secretion and charcoal meal test in mice. APG significantly reduced diarrhoea and also produced antimotility and antisecretory activity in castor oil model. These results indicate that APG is an active ingredient of Mebarid in treating diarrhoea.