The present study was designed to explore the anthelmintic activity of different extracts of plant Coccinia indica (fruits) using petroleum ether, ethyl acetate methanol and water as solvents. Various concentrations (25 and 50mg/ml) of all the extracts were tested, which involved determination of time of paralysis and time of death of the worms. It was compared with Albendazole as standard reference and normal saline as control. The study indicated the potential usefulness of Coccinia indica against earthworm infections.