Gabapentin and pregabalin are widely used therapeutic agents in patients with diabetic neuropathic pain. Their use has also brought about a wide number of adverse drug reactions. The aim of the study is to evaluate serious and/or unexpected adverse drug reactions associated with gabapentin and pregabalin in patients with painful diabetic peripheralneuropathy. In this study the adverse drug reactions were assessed and graded according to WHO Causality scale(Naranjo Causality scale),Severity(Modified Hartwig and Siegel scale),Preventability(Schumock and Thornton scale).Patients who were 18-75 years of age with pain attributing to diabetic neuropathy were included in the analysis. Data regarding demographic details, medicalhistory, allergichistory, details of diabetic peripheral neuropathy were documented. All the adverse drug reactions occurred was documented in Central Drugs Standard Control Organization (CDSCO) ADR form and reported to Pharmacovigilance committee at Department of Pharmacology in Sree Balaji Medical College. In a total of 100 patients with painful diabetic peripheral neuropathy, 42 were observed with Adverse Drug Reactions out of which patients treated with pregabalin has reported less ADRs when compared to patients treated with gabapentin. These ADRs were observed and graded according to WHO Causality, Severity and Preventability scale.