Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2017 Vol: 9 Issue: 11

Estimation of Ribociclib in Human Plasma Samples by LC-ESI-MS/MS

Abstract

A validated Ribociclib bioanalytical method was developed by HPLC-ESI-MS/MS using stationary phase Zorbax SB-C18, 4.6 × 75 mm, 3.5 μm, 80 Å column and mobile phase was used 5mM ammonium formate: acetonitirle (10:90 v/v). The Ribociclib and Ribociclib-D6 were identified using ESI mode at m/z 435.5 /112.1 and Ribociclib-D6 (IS) at 441.7/112.1. The correlation coefficient is ≥ 0.998 with linearity range 50.00-10000.00 pg/mL.

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