This paper establishes the affect factors framework of Marine technology innovation in Zhejiang Province, China. According to the affect factors, we do questionnaire survey on 30 marine pharmaceutical enterprises of Zhejiang Province. A structural equation model is established to make an empirical study on influence factors of marine technology innovation based on the objective environment of Zhejiang Province, China. Its conclusion indicates that marine technology human resources, Marine science and technology policy, financing environment, infrastructure and Marine technology platform, Marine cultural environment, marketization degree, natural resources, R&D spending , industrial structure optimization, have an effect on marine technology innovation. And, the most effective factor is the marine science and technology policy. It’s the affected by the delay of the planned economy. The tilt of the policy can effectively promote the Marine science and technology progress, and promote the technology commercialization.