In this work 1-ethyl-3-methylimidazolium tetrafluor oborate, (EMIMBF 4 ) a hydrophilic room temperature ionic liquid (RTIL) was used as a binder to make a new ki nd of ionic liquid-nickel hexacyanoferrate nanopart icles (NiHCF-NP) gel modified electrode, which was charac terized by cyclic voltammetry. The modified electro de showed good electrocatalytic behavior towards the o xidation of acetaminophen with an enhancement of pe ak current and reduction in overpotential. The modifie d electrode exhibited good linear relation in the c oncentration range from 1.5 μ M to 1.5 mM for the quantitative analysis of acetam inophen with a limit of detection of 0.51 μ M (3 σ ).