Teucrium polium is an old medicinal plant which has been used due to its antimicrobial- anti fungal properties. The goal of this research was to study the effects of Teucrium polium aquatic extract on blood cell parameters of Candida albicans infected animal model.72 female mice were divided randomly in five groups including control, candida, placebo, and three experimental groups. Aquatic extract was injected in peritoneum in 50,100 and 200 mg/kg doses for 20 days. Physiological serum was used as placebo group and the effect of extract on cells and blood parameters and disease improvement were evaluated. Obtained data were analyzed using SPSS program and means were compared using Duncan’s multiple ranges test. According to results, the extract reduced red blood cells and hemoglobin significantly. By improving infection, white blood cells were in normal level. Hematocrit amount was reduced in proportion to candida group. MCV, MCH, MCHC, and monocyte amounts were not different in experimental groups and candida group. Platelets amount was not significantly different from control and candida groups. Lymphocytes amount was increased in proportion to control group significantly. Neutrophils amount was increased in all groups significantly in proportion to candida group. In general, the extract of Teucrium polium could affect blood cells toward controlling Candida albicans pathogen.