Different formulae were used to prepare Artemether/Lumefantrinetablets using direct compression and wet granulation methods of preparation. Tablets of Lumefantrine and Artemether were prepared in different concentrations with: Microcrystalline cellulose (as diluent), HPMC and Polyvinylpyrrolidone (as binder), Croscarmellose sodium, Crospovidone and starch 1500 (as disintegrant), Colloidal Silicon dioxide (as glident), Polysorbate 80 (as surfactant), PEG (as dissolution enhancer), Magnesium stearate and sodium stearylfumarate (as lubricant).The different formulations of Artemether and lumefantrine tablets were evaluated for: weight variation, uniformity of tablets thickness and diameter, friability, hardness, disintegration and dissolution for Artemether and Lumefantrine.