The current study is to investigate the influence, concentrations crude of oil on the oxygen dissolved of the fresh water fish Barabus luteus and Liza Abu in different concentrations (2,5,10,15 and 20ml/L) and (6, 24 and 72 hours) periods of exposure. Found that the concentrations of crude oil had varied values with different values of oxygen dissolved. It was also observed that the Liza Abu fish more sensitive and affected by the fish Barabus luteus, Relationship between crude oil concentrations, and the oxygen dissolved where the, 15 and 20 ml/l of crude oil concentration recorded severe reduction in oxygen dissolved. The amounts of oxygen dissolved was observed to decrease in 6-hours period at 15 ml (2.7 mg/L and 20 ml/(2.3 mg/l)). Extermination of some biochemical composition showed that value of liver and muscle glycogen content significant decrease and revealed a negative correlation combined with the highest oil concentrations. As well, values of blood glucose show significant increase with all concentrations of crude oil the 72 hours recorded increased (35.07 ± 2.18 mg/l for juveniles Liza Abu and 47.64 ± 3.04 mg/l in the blood glucose of juveniles Barabus luteus and positive correlation.