Diabetes is a group of diseases with common numerous features, increased blood glucose is by definition the most obvious point. Our goal is to study the impact of drugs and anthropometric factors on some serum parameters among a representative sample of diabetic women with cardiovascular complications in Mascara city (Algeria). 70 type 2 diabetic women participated in this study over a period of nine months (from August 2014 to April 2015) with a mean age of 61 ± 7 years. Our results indicate a dominance of patients in 66-70 age bracket, almost 75,7% of women are overweight and 22,9% are obese. The mean of waist circumference is 102 ± 9 that of hip circumference is 107 ± 16. The waist hip ratio is 0.97 ± 0.18, systolic blood pressure is an average of 128 ± 20 and diastolic blood pressure is 70 ± 10. About cardiovascular complications, 98,6% of patients have high blood pressure, 18,6% left ventricular hypertrophy, 5,7% coronary insufficiency, 12,9% have had myocardial infarction and 10% cerebrovascular accident. We have noted a significant dependency between biguanides and fasting serum glucose levels (P = 0.023) in the risk of error 5%, the results showed that the HbA1c is strongly depends on the treatment with fast acting insulin analog, with significance (P = 0.008), total cholesterol depends significantly on the use of Meglitinide (glinides) and the basal insulin analog with an estimated significance level was respectively (P = 0.022) and (P = 0.042). The results of the statistical analysis show a significant relationship between triglycerides and basal insulin analog (P = 0.032), a significant relationship exists also between urea, clearance and Meglitinide (glinides) with such degree of significance (P = 0.018) and (P = 0.021) respectively. A negative significant correlation between HbA1c and hip circumference (P = 0,004) and between microalbuminuria and hip circumference (P = 0,012), microalbuminuria and the waist hip ratio (P = 0,006).