Salacia fruticosa is a medicinal tree used to treat several inflammatory disorders in the Indian traditional ayurvedic system of medicine. The aim of current study is to evaluate anti-inflammatory activity of the methanolic, aqeous extracts of the leaves of Salacia fruticosa support the pharmacological claims. The study was carried out by using rats. The methanol and aqeous extracts were precipitated using soxhlet extraction process. The inflammatory activity of the methanolic extract and the aqeous of the leaves of Salacia fruticosa were studied using egg albumin induced paw odema (in-vitro) and carrageenan induced paw odema (in-vivo), egg albunin induced paw odema (in-vivo) models. The methanolic and aqeous extract of the leaves of Salacia fruticosa at a doses of 25-800 microgram/ml (P.O) (oral administration) showed a dose dependent and significant inhibition of anti-inflammatory activity models. Indomethacin is used as a standard drug.