Supraclavicular brachial plexus block provides surgical anaesthesia and analgesia of upper extremity. Itis safe, effective, anaesthesia with good postoperative analgesia. This study was conducted to compare the postoperative analgesic efficacy and safety of dexmedetomidine for brachial plexus blockade along with bupivacaine and lignocaine.This prospective double blind study was conducted on 50 patients of age 18 to 60 years posted for various upper limb surgeries and randomly allocated into two equal groups of 25 each. Control group-C received solution of 42ml containing bupivacaine 0.5% 20 ml and lignocaine with adrenaline 2%(1:200000)20ml plus2 ml normal saline, dexmedetomidine group-D received solution of 42ml containing bupivacaine 0.5% 20ml and lignocaine with adrenaline 2% (1:200000)20ml plus dexmedetomidine 50mcg(in 2 ml normal saline). Assessment of motor and sensory blockade, pulse, systolic blood pressure, respiration and side effects were noted every 5 minutes for first 30 minute and every 15 minute till end of surgery. Duration of analgesia and incidence of various complications following the procedure were observed. Results are analyzed using paired student t- test significance noted if p value is <0.005. It was observed that in the dexmedetomidine group the duration of motor and sensory blockade was longer with better hemodynamic stability and greater postoperative analgesia, which is statistically significant when compared to control group.